Eighth secret agent (Arie curly, Babe Cabita, Bintang Bete, Ernest Prakasa, Fico Fachriza, Ge Pamungkas, Kemal Palevi, Mongol) using the pseudonym COMIC 8 back in action. Those who had been framed by THE KING (Sophia Latjuba) together with the troops led by Isa (Donny Alamsyah) and Bella (Hannah Al Rashid), as well as a cunning conspirator named Dr. Pandji (banner Pragiwaksono); forced bet will have their survival, in the online gambling game spread to the King of Gambling worldwide. Level-by-Level must pass eight of them. From the plot hit squad called The Hunters (Barry Prima, George Rudy, Lidya Kandou, Billy Chong, Salah Solihun, Sacha Stevenson) who continue to hunt for slay them, until Master Martial called The Ghost (Yayan Ruhian) that come to the surface world ; only to face a Cabiita Babe. At the same time, Indro Warkop are also being hunted Interpol agent named Chintya (Prisia Nasution), eventually also got stuck into games or Online Gambling in the hidden island along with a security guard (Ence Bagus) were present at the time and the wrong place; into a Cage Fighting arena, for fighter-fighter against the powerful there. Funny events that will solve the laughter continues to occur accompany all their actions, which for the sake of an unexpected twist twist ready waiting for the audience to follow the adventures of a hilarious nan exciting sequel Comic 8: Casino Kings Part 2 of this. In addition to the names above, the film is also enlivened by the presence of Nikita Mirzani, Agung Hercules, Agus Kuncoro, Candil, Gandhi Fernando, Cak Lontong, Joe P Project, Boy William, Ray Sahetapy and Good Neutral.
